How many drug targets are there?

@article{Overington2006HowMD,
  title={How many drug targets are there?},
  author={John P. Overington and Bissan Al-Lazikani and Andrew L. Hopkins},
  journal={Nature Reviews Drug Discovery},
  year={2006},
  volume={5},
  pages={993-996}
}
For the past decade, the number of molecular targets for approved drugs has been debated. Here, we reconcile apparently contradictory previous reports into a comprehensive survey, and propose a consensus number of current drug targets for all classes of approved therapeutic drugs. One striking feature is the relatively constant historical rate of target innovation (the rate at which drugs against new targets are launched); however, the rate of developing drugs against new families is… 

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