How long should we treat community-acquired pneumonia?

  title={How long should we treat community-acquired pneumonia?},
  author={Nikole M. Scalera and Thomas M. Jr File},
  journal={Current Opinion in Infectious Diseases},
  • N. ScaleraT. File
  • Published 1 April 2007
  • Medicine, Biology
  • Current Opinion in Infectious Diseases
Purpose of review The studies reviewed in this article suggest that a shorter duration of antibiotic therapy is comparable to standard therapy in the treatment of community-acquired pneumonia and promotes reduction of adverse events, microbial resistance, cost, and improved patient compliance. Recent findings Community-acquired pneumonia has traditionally been treated with a 7–14-day course of antimicrobial therapy. Since there have been few well controlled trials regarding the optimal duration… 

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Short-Course Antimicrobial Therapy for Community-Acquired Pneumonia

Conclusions are drawn that remaining questions regarding the influence of patient selection, disease severity or choice of antimicrobial for short-course therapy indicate the need for further randomized controlled clinical trials in this area of research.

Value of short-course antimicrobial therapy in community-acquired pneumonia.

  • F. BlasiP. Tarsia
  • Medicine, Biology
    International journal of antimicrobial agents
  • 2005

Short-duration therapy for respiratory tract infections.

  • D. Goff
  • Medicine, Biology
    The Annals of pharmacotherapy
  • 2004
Short-course therapy for CARTIs (such as acute bacterial maxillary sinusitis, acute exacerbations of chronic bronchitis, community-acquired pneumonia) has been demonstrated to be effective with antibiotics from several different classes, including the ketolide antimicrobials.

Clinical efficacy of newer agents in short-duration therapy for community-acquired pneumonia.

  • T. File
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2004
Available data suggest that with appropriate antibiotic selection, based on appropriate spectrum, potency, and pharmacokinetic/pharmacodynamic profile, lower respiratory tract infections in outpatients can be successfully treated in <7 days rather than the 7-14 days currently recommended.

What is the optimal duration of antibiotic therapy?

  • J. Paul
  • Medicine, Biology
    BMJ : British Medical Journal
  • 2006
Evidence in favour of a total of three days' treatment for uncomplicated cases of community acquired pneumonia is presented, suggesting that current guidelines recommending 7-10 days should be revised.

Short courses of antibiotic in acute otitis media and sinusitis infections.

  • M. Pichicero
  • Medicine
    The Journal of international medical research
  • 2000
Shortened-course therapy with agents such as cefuroxime axetil has the potential to improve patient compliance and so reduce the rate of clinical failure and the emergence of resistant strains.

Antimicrobial therapy of community-acquired pneumonia

Length of antibiotic therapy in in-patients with primary pneumonias.

It is suggested that in primary pneumonia it is more rational to stop antibiotics after the patient has been afebrile for 24 hours, which leads to a shorter stay in hospital and to the use of less antibiotic.