How life changes itself: the Read-Write (RW) genome.

@article{Shapiro2013HowLC,
  title={How life changes itself: the Read-Write (RW) genome.},
  author={James A. Shapiro},
  journal={Physics of life reviews},
  year={2013},
  volume={10 3},
  pages={
          287-323
        }
}
The genome has traditionally been treated as a Read-Only Memory (ROM) subject to change by copying errors and accidents. In this review, I propose that we need to change that perspective and understand the genome as an intricately formatted Read-Write (RW) data storage system constantly subject to cellular modifications and inscriptions. Cells operate under changing conditions and are continually modifying themselves by genome inscriptions. These inscriptions occur over three distinct time… CONTINUE READING
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