How leukocytes cross the vascular endothelium

  title={How leukocytes cross the vascular endothelium},
  author={D. Vestweber},
  journal={Nature Reviews Immunology},
  • D. Vestweber
  • Published 2015
  • Biology, Medicine
  • Nature Reviews Immunology
  • Immune responses depend on the ability of leukocytes to move from the circulation into tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow them to cross the barrier of the blood vessel wall. This process is regulated by a concerted action between endothelial cells and leukocytes, whereby endothelial cells activate leukocytes and direct them to extravasation sites, and leukocytes in turn instruct endothelial cells to open a path for transmigration. This… CONTINUE READING
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