How is a co-methyl intermediate formed in the reaction of cobalamin-dependent methionine synthase? Theoretical evidence for a two-step methyl cation transfer mechanism.

Abstract

A methyl-Co(cobalamin) species has been characterized to be a crucial intermediate in the last step of the de novo biosynthesis of methionine catalyzed by cobalamin-dependent methionine synthase (MetH). However, exactly how it is formed is still an open question. In the present article, the formation of the methyl-Co(cobalamin) species in MetH has been… (More)
DOI: 10.1021/jp105729e

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