How ionic liquids can help to stabilize native proteins.

  title={How ionic liquids can help to stabilize native proteins.},
  author={Hermann Weing{\"a}rtner and Chiara Cabrele and Christian Herrmann},
  journal={Physical chemistry chemical physics : PCCP},
  volume={14 2},
The native state of a globular protein is essential for its biocatalytic function, but is marginally stable against unfolding. While unfolding equilibria are often reversible, folding intermediates and misfolds can promote irreversible protein aggregation into amorphous precipitates or highly ordered amyloid states. Addition of ionic liquids-low-melting organic salts-offers intriguing prospects for stabilizing native proteins and their enzymatic function against these deactivating reaction… CONTINUE READING
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