How introns influence and enhance eukaryotic gene expression.

@article{Hir2003HowII,
  title={How introns influence and enhance eukaryotic gene expression.},
  author={Herv{\'e} Le Hir and A. C. Nott and Melissa J. Moore},
  journal={Trends in biochemical sciences},
  year={2003},
  volume={28 4},
  pages={
          215-20
        }
}
Although it has been known since the late 1970s that intron-containing and intronless versions of otherwise identical genes can exhibit dramatically different expression profiles, the underlying molecular mechanisms have only lately come to light. This review summarizes recent progress in our understanding of how introns and the act of their removal by the spliceosome can influence and enhance almost every step of mRNA metabolism. A rudimentary understanding of these effects can prove… CONTINUE READING
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