How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts.

@article{Rhodes2003HowID,
  title={How inotropic drugs alter dynamic and static indices of cyclic myoplasmic [Ca2+] to contractility relationships in intact hearts.},
  author={Samhita Rhodes and Kristina M. Ropella and Amadou K. S. Camara and Qun Chen and Matthias L Riess and David F. Stowe},
  journal={Journal of cardiovascular pharmacology},
  year={2003},
  volume={42 4},
  pages={539-53}
}
The authors examined effects of positive (dopamine and digoxin) and negative (nifedipine and lidocaine) inotropic interventions on the instantaneous cyclic relationship between myoplasmic [Ca2+] and simultaneously developed left ventricular pressure (LVP) in intact guinea pig hearts. Novel indices were developed to quantify this relationship based on (1) transient [Ca2+] and LVP signal morphology, ie, maxima and minima, peak derivatives, beat areas, durations, and ratios of indices of LVP to… CONTINUE READING