How infection can incite sensitivity to food

@article{Verd2017HowIC,
  title={How infection can incite sensitivity to food},
  author={Elena F. Verd{\'u} and Alberto Caminero},
  journal={Science},
  year={2017},
  volume={356},
  pages={29 - 30}
}
Microbes can trigger chronic immune disorders to dietary antigens, such as in celiac disease Immune tolerance to dietary antigens is key to preventing undesirable responses to innocuous antigens ingested with food. On page 44 of this issue, Bouziat et al. (1) report how viral infection may break oral tolerance to dietary proteins. The findings provide an explanation for the known epidemiological association between viral infections and the onset of food sensitivities, such as celiac disease… 

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The possible link between coeliac and Kawasaki diseases in Brazil: a cross-sectional study

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References

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Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

A viral infection model that makes use of two reovirus strains that infect the intestine but differ in their immunopathological outcomes discovered that it can nonetheless disrupt intestinal immune homeostasis at inductive and effector sites of oral tolerance by suppressing peripheral regulatory T cell (pTreg) conversion and promoting TH1 immunity to dietary antigen.

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The importance of utilizing animal models and long-term clinical studies to gain insight into the mechanisms through which host–microbial interactions can influence host responses to gluten and how the interplay between host genetics, environmental factors and the intestinal microbiota might contribute to its pathogenesis is highlighted.

Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity.

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