How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

@article{Ristow2010HowIO,
  title={How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)},
  author={M. Ristow and K. Zarse},
  journal={Experimental Gerontology},
  year={2010},
  volume={45},
  pages={410-418}
}
  • M. Ristow, K. Zarse
  • Published 2010
  • Biology, Medicine
  • Experimental Gerontology
  • Recent evidence suggests that calorie restriction and specifically reduced glucose metabolism induces mitochondrial metabolism to extend life span in various model organisms, including Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans and possibly mice. In conflict with Harman's free radical theory of aging (FRTA), these effects may be due to increased formation of reactive oxygen species (ROS) within the mitochondria causing an adaptive response that culminates in… CONTINUE READING
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