How human neuroblastoma cells make morphine.

  title={How human neuroblastoma cells make morphine.},
  author={Chotima Boettcher and Monika Fellermeier and Christian Boettcher and Birgit Dr{\"a}ger and Meinhart H. Zenk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 24},
Recently, our laboratory demonstrated that human neuroblastoma cells (SH-SY5Y) are capable of synthesizing morphine, the major active metabolite of opium poppy. Now our experiments are further substantiated by extending the biochemical studies to the entire morphine pathway in this human cell line. L-[1,2,3-13C3]- and [ring-2',5',6'-2H3]dopa showed high isotopic enrichment and incorporation in both the isoquinoline and the benzyl moiety of the endogenous morphine. [2,2-2H2]Dopamine, however… CONTINUE READING
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