How homologous recombination maintains telomere integrity

@article{Tacconi2014HowHR,
  title={How homologous recombination maintains telomere integrity},
  author={Eliana M. C. Tacconi and Madalena Tarsounas},
  journal={Chromosoma},
  year={2014},
  volume={124},
  pages={119-130}
}
Telomeres protect the ends of linear chromosomes against loss of genetic information and inappropriate processing as damaged DNA and are therefore crucial to the maintenance of chromosome integrity. In addition to providing a pathway for genome-wide DNA repair, homologous recombination (HR) plays a key role in telomere replication and capping. Consistent with this, the genomic instability characteristic of HR-deficient cells and tumours is driven in part by telomere dysfunction. Here, we… CONTINUE READING

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