How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.

@article{Polikanov2012HowHF,
  title={How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.},
  author={Yury S Polikanov and Gregor M. Blaha and Thomas A Steitz},
  journal={Science},
  year={2012},
  volume={336 6083},
  pages={915-8}
}
Eubacteria inactivate their ribosomes as 100S dimers or 70S monomers upon entry into stationary phase. In Escherichia coli, 100S dimer formation is mediated by ribosome modulation factor (RMF) and hibernation promoting factor (HPF), or alternatively, the YfiA protein inactivates ribosomes as 70S monomers. Here, we present high-resolution crystal structures of the Thermus thermophilus 70S ribosome in complex with each of these stationary-phase factors. The binding site of RMF overlaps with that… CONTINUE READING
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  • H. Jin, A. C. Kelley, V. Ramakrishnan
  • Natl. Acad. Sci. U.S.A. 108,
  • 1579

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