How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributions

@article{Dessalles2019HowHT,
  title={How heterogeneous thymic output and homeostatic proliferation shape naive T cell receptor clone abundance distributions},
  author={Renaud Dessalles and Maria R. D’Orsogna and Tom Chou},
  journal={bioRxiv},
  year={2019}
}
The set of T cells that express the same T cell receptor (TCR) sequence represent a T cell clone. The number of different naive T cell clones in an organism reflects the number of different T cell receptors (TCRs) arising from recombination of the V(D)J gene segments during T cell development in the thymus. TCR diversity and more specifically, the clone abundance distribution is an important factor in immune function. Specific recombination patterns occur more frequently than others while… Expand
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