How good are predictions of protein secondary structure?

  title={How good are predictions of protein secondary structure?},
  author={Wolfgang Kabsch and Christian A. Sander},
  journal={FEBS Letters},

Progress of 1D protein structure prediction at last

Accuracy of predicting protein secondary structure and solvent accessibility from sequence information has been improved significantly by using information contained in multiple sequence alignments

The protein structure code: what is its present status?

The method based on sequence similarity can improve the accuracy of prediction by expressing explicitly the homology of the protein to be predicted with proteins in the database, and can be used for modeling homologous proteins by aiding in amino acid sequence alignments.

Predicting the conformation of proteins from sequences. Progress and future progress

  • S. Benner
  • Biology
    Journal of molecular recognition : JMR
  • 1995
This work avoids ‘three state per residue scores’ as a tool for evaluating a prediction, and focuses instead on efforts to understand why a prediction is successful when it is successful, and why it fails when it fails.

On predicting secondary structure transition

It is demonstrated that predicting structure transition with high degree of certainty is possible and the algorithm was able to get as high as 97.5% of prediction accuracy.

Protein structure prediction.




Evaluation of secondary structure predictions in proteins.

  • J. Lenstra
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1977

Theory of protein secondary structure and algorithm of its prediction

A molecular theory of protein secondary structure is presented that takes account of both local interactions inside each chain region and long‐range interactions between different regions,

Protein secondary structure. Studies on the limits of prediction accuracy.

The results indicate that nearest neighbor prediction techniques are insensitive to various assignment criteria for the secondary structural spans, have nearly achieved their upper limit of prediction accuracy, and can be somewhat improved through the use of stereochemical weighting factors and conformational parameters derived from the four structural groups.

Anti-influenza response achieved by immunization with a synthetic conjugate.

Preliminary results indicate that C3H/DiSn mice immunized with the peptide--tetanus toxoid conjugate are partially protected against a further challenge with A/Texas mouse-adapted influenza virus.