How glucagon-like is glucagon-like peptide-1?

  title={How glucagon-like is glucagon-like peptide-1?},
  author={Dr. M. Ghiglione and Lars Otto Uttenthal and Sunny K. George and Stephen R. Bloom},
Although glucagon-like peptide-1 has the appearance of a glucagon-homologue that may be co-secreted with glucagon, synthetic glucagon-like peptide-1-(1–37) does not significantly affect plasma glucose and insulin concentrations when administered at high doses (100 and 400 μg) to cortisone-pretreated rabbits. This synthetic preparation thus lacks the primary metabolic effect of glucagon at the doses tested. An intra- or extra-pancreatic role of glucagon-like peptide-1 has yet to be discovered.