How genetic errors in GPCRs affect their function: Possible therapeutic strategies

@inproceedings{Stoy2015HowGE,
  title={How genetic errors in GPCRs affect their function: Possible therapeutic strategies},
  author={Henriette Stoy and Vsevolod V. Gurevich},
  booktitle={Genes & diseases},
  year={2015}
}
Activating and inactivating mutations in numerous human G protein-coupled receptors (GPCRs) are associated with a wide range of disease phenotypes. Here we use several class A GPCRs with a particularly large set of identified disease-associated mutations, many of which were biochemically characterized, along with known GPCR structures and current models of GPCR activation, to understand the molecular mechanisms yielding pathological phenotypes. Based on this mechanistic understanding we also… CONTINUE READING
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