How early can we predict Alzheimer's disease using computational anatomy?

  title={How early can we predict Alzheimer's disease using computational anatomy?},
  author={S. Adaszewski and J. Dukart and F. Kherif and R. Frackowiak and Alzheimer's Disease Neuroimaging Initiative},
  journal={Neurobiology of Aging},
  • S. Adaszewski, J. Dukart, +2 authors Alzheimer's Disease Neuroimaging Initiative
  • Published 2013
  • Psychology, Medicine
  • Neurobiology of Aging
  • Computational anatomy with magnetic resonance imaging (MRI) is well established as a noninvasive biomarker of Alzheimer's disease (AD); however, there is less certainty about its dependency on the staging of AD. We use classical group analyses and automated machine learning classification of standard structural MRI scans to investigate AD diagnostic accuracy from the preclinical phase to clinical dementia. Longitudinal data from the Alzheimer's Disease Neuroimaging Initiative were stratified… CONTINUE READING
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