How dynein and microtubules rotate the nucleus.

@article{Wu2011HowDA,
  title={How dynein and microtubules rotate the nucleus.},
  author={Jingjing Wu and Kristen C Lee and Richard B. Dickinson and Tanmay P Lele},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 10},
  pages={
          2666-74
        }
}
In living cells, a fluctuating torque is exerted on the nuclear surface but the origin of the torque is unclear. In this study, we found that the nuclear rotation angle is directionally persistent on a time scale of tens of minutes, but rotationally diffusive on longer time scales. Rotation required the activity of the microtubule motor dynein. We formulated a model based on microtubules undergoing dynamic instability, with tensional forces between a stationary centrosome and the nuclear… CONTINUE READING

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