How drugs decrease fracture risk: lessons from trials.

@article{Cummings2002HowDD,
  title={How drugs decrease fracture risk: lessons from trials.},
  author={Steve Cummings},
  journal={Journal of musculoskeletal & neuronal interactions},
  year={2002},
  volume={2 3},
  pages={198-200}
}
  • Steve Cummings
  • Published 2002 in
    Journal of musculoskeletal & neuronal…
In women with osteoporosis, each 1% improvement in spine BMD (by DXA) is expected to reduce vertebral fracture risk by about 4%. However, randomized trials of antiresorptive agents show that 1 to 6% improvements in spine BMD reduce vertebral fracture risk by 35 to 50%. Less 20% of the decreased spine fracture risk produced by alendronate or raloxifene be explained by improvement in spine BMD. The discrepancy is even greater during the first year or two of treatment when 1 to 4% improvements in… CONTINUE READING
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