How dormant origins promote complete genome replication.

  title={How dormant origins promote complete genome replication.},
  author={J Julian Blow and Xin Quan Ge and Dean A Jackson},
  journal={Trends in biochemical sciences},
  volume={36 8},
Many replication origins that are licensed by loading MCM2-7 complexes in G1 are not normally used. Activation of these dormant origins during S phase provides a first line of defence for the genome if replication is inhibited. When replication forks fail, dormant origins are activated within regions of the genome currently engaged in replication. At the same time, DNA damage-response kinases activated by the stalled forks preferentially suppress the assembly of new replication factories… CONTINUE READING

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