How does zinc supplementation benefit anorexia nervosa?

@article{Birmingham2006HowDZ,
  title={How does zinc supplementation benefit anorexia nervosa?},
  author={C. Laird Birmingham and Susan Gritzner},
  journal={Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity},
  year={2006},
  volume={11},
  pages={e109-e111}
}
Background: A randomized controlled trial of zinc supplementation in anorexia nervosa (AN) reported a two-fold increase of the rate of increase of body mass index (BMI) in the zinc group. Zinc is inexpensive, readily available and free of significant side effects. However, oral zinc supplementation is infrequently prescribed as an adjunctive treatment for AN. Understanding the mechanism of action of zinc may increase its use. Hypothesis: Low zinc intake, which is very common in AN, adversely… 
Micronutrient Status in 153 Patients with Anorexia Nervosa
TLDR
It is suggested that micronutrient status is often altered in Anorexia Nervosa patients, which may contribute to neuropsychiatric dysfunction and monitoring of micronUTrients and correction of deficits should be included in the routine care of AN patients.
Micronutrient deficiencies and supplementation in anorexia and bulimia nervosa: a review of literature.
  • J. Setnick
  • Medicine
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2010
TLDR
Because of the widely varying eating practices from patient to patient and the current lack of data controlling for nutrient self-supplementation, nutrition assessment performed by a nutrition professional via food intake history may be more practical than laboratory tests and more accurate than current food intake for determining potential micronutrient deficiencies.
Revisión del tratamiento dietético-nutricional de la anorexia nerviosa
TLDR
A literature review was performed in Medline, searching for articles related to the dietary and nutritional management of anorexia nervosa and published over the last five years, finding 102 articles that summarized the different therapeutic contexts and objectives.
Micronutrients Deficiencies in 374 Severely Malnourished Anorexia Nervosa Inpatients
TLDR
Severely malnourished AN patients have many micronutrient deficiencies and should be monitored and supplemented to prevent deficiencies related complications and to improve nutritional status.
Anorexia Nervosa—What Has Changed in the State of Knowledge about Nutritional Rehabilitation for Patients over the Past 10 Years? A Review of Literature
TLDR
The aim of this paper is to systematize the current reports on nutritional rehabilitation in AN, to present the results of studies on the safe supplementation of patients and its potential impact on improving prognosis and the healing process, and to present previous reports on the potential benefits of introducing vitamin, pro-and prebiotic and fatty acid supplementation.
Differences in serum zn levels in acutely ill and recovered adolescents and young adults with anorexia nervosa--a pilot study.
TLDR
Preliminary evidence for differences in serum Zn status in recovered patients with AN is provided, in particular as regards Ca²⁺ and phosphorus-containing foods, but because of limited statistical power, future research involving larger samples is necessary.
Somatic complications and nutritional management of anorexia nervosa
Summary Anorexia nervosa (AN) in its two major types (restricting type and binge-eating/purging type) is one of the most frequent and serious eating disorder. Severe undernutrition due to intake
DISEASES AND CONDITIONS ASSOCIATED WITH ZINC DEFICIENCY. SERUM ZINC IN PREGNANT WOMEN WITH REPRODUCTIVE FAILURES AND SERUM ZINC IN CHILDREN WITH TYPE I DIABETES
TLDR
It is considered that the addition of zinc to the diet could improve the current status of patients with zinc deficiency and could even lead to survival of children with various diseases and conditions.
Differences in serum zinc levels in acutely ill and remitted adolescents and young adults with bulimia nervosa in comparison with healthy controls – a cross-sectional pilot study
TLDR
Preliminary evidence is provided that the underlying factors for changes in Zn serum concentrations in young patients with BN do not vary with regard to the stage of illness, and further prospective research is needed to disentangle the possible interplay between serum Zn status and bulimic eating behaviors.
Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews
TLDR
Clinicians are offered an overview of the evidence-based data in the literature concerning the medication (psychotropic drugs and medication for somatic and nutritional complications) in the field of anorexia nervosa since the 1960s to draw practical conclusions for everyday practise and future research.
...
1
2
3
4
...

References

SHOWING 1-10 OF 51 REFERENCES
Controlled trial of zinc supplementation in anorexia nervosa.
TLDR
The rate of increase in BMI of the zinc supplemented group was twice that of the placebo group, and this difference was statistically significant (p = .03).
Oral zinc supplementation in anorexia nervosa.
  • S. Safai-Kutti
  • Medicine
    Acta psychiatrica Scandinavica. Supplementum
  • 1990
TLDR
The design of an ongoing multicenter placebo-controlled clinical trial of zinc supplementation to patients with AN is described, and the maximum gradual weight gain of 57% was encountered in one patient after 24 months of zinc therapy.
Zinc supplementation in the treatment of anorexia nervosa
TLDR
Randomised, double-blind, controlled clinical trials indicate that zinc therapy enhances the rate of recovery in anorexia nervosa patients by increasing weight gain and improving their levels of anxiety and depression.
Zinc deficiency in anorexia nervosa.
TLDR
The data suggest that individuals with anorexia nervosa may be at risk for zinc deficiency and may respond favorably after zinc supplementation and is suggested to be compromised due to an inadequate zinc intake.
The role of zinc in anorexia nervosa: etiology and treatment.
  • R. Bakan
  • Biology, Medicine
    Medical hypotheses
  • 1979
TLDR
It is proposed that effectiveness in the treatment of anorexia nervosa is proposed, and stress, estrogen and dietary habits may also be involved in the complex of factors which create or exacerbate a zinc deficiency and result in anorexa nervosa.
Dietary zinc intake of vegetarian and nonvegetarian patients with anorexia nervosa.
TLDR
It is indicated that zinc intake should be routinely assessed in anorexia nervosa patients and that zinc supplementation of their diets may be indicated.
Zinc status before and after zinc supplementation of eating disorder patients.
TLDR
It is suggested that Zn deficiency may act as a "sustaining" factor for abnormal eating behavior in certain eating disorder patients.
Hormonal effects of zinc on growth in children
  • A. Favier
  • Biology, Medicine
    Biological Trace Element Research
  • 2007
TLDR
Zinc supplementation has proven effective in many studies, mainly in children where zinc deficiency has first been found, and makes it possible in certain cases to overcome resistance to growth hormone treatment.
Assessment of macronutrient and micronutrient intake in women with anorexia nervosa.
TLDR
The agreement between total energy intake and predicted energy expenditure supports the overall utility of the diet history in the nutritional assessment of patients with AN and demonstrates significant micronutrient deficiencies in this population.
Acquired Zinc Deficiency in Association with Anorexia Nervosa: Case Report and Review of the Literature
TLDR
It is believed that screening zinc levels in patients with anorexia nervosa with prominent cutaneous findings should be considered, since the cutaneous stigmata of zinc deficiency and anorexa nervosa can initially be subtle and occasionally overlap.
...
1
2
3
4
5
...