How does the structure of nitroxides modulate their efficacy as antioxidants against protein - derived free radicals ?

Abstract

Radical mediated protein oxidation occurs during aging and some human diseases (e.g. cataracts, heart disease). Tyrosine (Tyr) and tryptophan (Trp) residues are particularly susceptible to oxidation, resulting in the formation of protein-bound Tyr and Trp radicals which can readily propagate damage to other cellular components. As protein oxidation is… (More)

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