How does stress increase risk of drug abuse and relapse?

  title={How does stress increase risk of drug abuse and relapse?},
  author={Rajita Sinha},
Rationale: The notion that stress leads to drug abuse in vulnerable individuals and relapse in addicts is not new. Most major theories of addiction postulate that stress plays an important role in increasing drug use and relapse. Several animal studies and some human laboratory studies have shown that stress exposure enhances drug self-administration. Although clinical observations suggest that exposure to stress increases drug use, and are associated with craving and relapse in addicts, human… CONTINUE READING
Highly Influential
This paper has highly influenced 37 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 476 extracted citations

Nicotine withdrawal alters neural responses to psychosocial stress

Psychopharmacology • 2016
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 116 references

Cloni - dine blocks stress - induced reinstatement of heroin seeking in rats : an effect independent of locus coeruleus noradrenergic neurons

KJ Sher, RW Levenson
Eur J Neurosci • 2000

Dis - connection of the anterior cingulate cortex and nucleus accumbens core impairs pavlovian approach behavior : further evidence for limbic corticalventral striatopallidal systems

WE Pelham, AR Lang, +5 authors KE Greenslade
Behav Neurosci • 2000

Similar Papers

Loading similar papers…