How does salt retention raise blood pressure?

  title={How does salt retention raise blood pressure?},
  author={Mordecai P. Blaustein and Jin Zhang and Ling Chen and Bruce P. M. Hamilton},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={290 3},
A critical question in hypertension research is: How is long-term blood pressure controlled? Excessive NaCl ingestion or NaCl retention by the kidneys and the consequent tendency toward plasma volume expansion lead to hypertension. Nevertheless, the precise mechanisms linking salt to high blood pressure are unresolved. The discovery of endogenous ouabain, an adrenocortical hormone, provided an important clue. Ouabain, a selective Na+ pump inhibitor, has cardiotonic and vasotonic effects. Plasma… CONTINUE READING


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