How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?

@article{Lindsay1994HowDR,
  title={How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?},
  author={Allan R. G. Lindsay and Andrew Tinker and Alan R. Williams},
  journal={The Journal of General Physiology},
  year={1994},
  volume={104},
  pages={425 - 447}
}
Under appropriate conditions, the interaction of the plant alkaloid ryanodine with a single cardiac sarcoplasmic reticulum Ca(2+)-release channel results in a profound modification of both channel gating and conduction. On modification, the channel undergoes a dramatic increase in open probability and a change in single-channel conductance. In this paper we aim to provide a mechanistic framework for the interpretation of the altered conductance seen after ryanodine binding to the channel… CONTINUE READING

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The effects of inhibitors of sarcoplasmic reticulum function on the systolic Ca ~ + transient in rat ventricular myocytes

  • M. Radermacher, T. Wagenknecht, +4 authors S. Fleischer
  • Journal of Physiology .
  • 1993

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