How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology.

@article{Borghammer2018HowDP,
  title={How does parkinson's disease begin? Perspectives on neuroanatomical pathways, prions, and histology.},
  author={Per Borghammer},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2018},
  volume={33 1},
  pages={
          48-57
        }
}
Parkinson's disease (PD) is a multisystem disorder with involvement of the peripheral nervous system. Misfolding and aggregation of α-synuclein is central to the pathogenesis of PD, and it has been postulated that the disease may originate in olfactory and gastrointestinal nerve terminals. The prion-like behavior of α-synuclein has been convincingly demonstrated in vitro and in animal models of PD. Lewy-type pathology have been detected in peripheral organs many years prior to PD diagnosis, and… CONTINUE READING

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