How does noncoding transcription regulate Hox genes?

@article{Lempradl2008HowDN,
  title={How does noncoding transcription regulate Hox genes?},
  author={Adelheid Lempradl and Leonie Ringrose},
  journal={BioEssays},
  year={2008},
  volume={30}
}
Noncoding RNA has arrived at centre stage in recent years with the discovery of “hidden transcriptomes” in many higher organisms. Over two decades ago, noncoding transcripts were discovered in Drosophila Hox complexes, but their function has remained elusive. Recent studies 1–3 have examined the role of these noncoding RNAs in Hox gene regulation, and have generated a fierce debate as to whether the noncoding transcripts are important for silencing or activation. Here we review the evidence… Expand
Regulatory noncoding RNAs at Hox loci.
TLDR
The role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long nc RNAs that may repress a Hox in cis in Dosophila by transcriptional interference, and on a novel long nCRNA that functions in trans to regulate Hox gene mammals are focused on. Expand
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Noncoding RNAs in Polycomb and Trithorax Regulation: A Quantitative Perspective.
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  • Biology, Medicine
  • Annual review of genetics
  • 2017
TLDR
It is proposed that integrating the current knowledge of noncoding RNA into a quantitative biochemical and theoretical framework for PcG and TrxG regulation has the potential to reconcile several apparently conflicting models and identifies fascinating questions for future research. Expand
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TLDR
With the recent discovery that much of the DNA in genomes is transcribed into ncRNAs with yet unknown function, it is likely that future studies will reveal many more ncRNA regulators of transcription. Expand
From bacteria to humans, chromatin to elongation, and activation to repression: The expanding roles of noncoding RNAs in regulating transcription.
TLDR
With the recent discovery that much of the DNA in genomes is transcribed into ncRNAs with yet unknown function, it is likely that future studies will reveal many more ncRNA regulators of transcription. Expand
Long noncoding RNAs: functional surprises from the RNA world.
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Non-coding RNAs in Polycomb/Trithorax regulation
TLDR
Current evidence for the molecular mechanisms by which non-coding RNAs may recruit PcG and TrxG proteins, switch gene expression states, and maintain epigenetic memory is discussed. Expand
A double-edged sword to force posterior dominance of Hox genes.
  • N. P. Singh, R. Mishra
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2008
TLDR
Two miRNAs encoded from the same locus target 3' untranslated regions of anterior hox genes, Antp, Ubx and abd-A to establish the dominance of posterior hox gene Abd-B in its expression domain. Expand
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