How does increased cardiac output increase shunt in pulmonary edema?

@article{Breen1982HowDI,
  title={How does increased cardiac output increase shunt in pulmonary edema?},
  author={Peter H. Breen and Paul T Schumacker and G{\"o}ran Hedenstierna and Jameel Ali and Peter D. Wagner and Laura D Wood},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1982},
  volume={53 5},
  pages={1273-80}
}
In pulmonary edema, the relationship between cardiac output (QT) and shunt (QS/QT) may be due to a diffusion barrier for O2 transfer (incomplete alveolar-capillary equilibration) or to redistribution of increased pulmonary blood flow toward edematous units. We compared transfer of O2 and multiple inert gases in the left (LLL) and right (RLL) lower lobes and in the whole lungs of eight dogs having oleic acid edema in LLL. When mean QT was increased from 3.0 to 5.5 l X min-1 during O2 ventilation… CONTINUE READING