How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?

  title={How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?},
  author={Madson Queiroz Almeida and Constantine A Stratakis},
  journal={Molecular and cellular endocrinology},
  volume={336 1-2},
The overwhelming majority of benign lesions of the adrenal cortex leading to Cushing syndrome are linked to one or another abnormality of the cAMP signaling pathway. A small number of both massive macronodular adrenocortical disease and cortisol-producing adenomas harbor somatic GNAS mutations. Micronodular adrenocortical hyperplasias are either pigmented (the classic form being that of primary pigmented nodular adrenocortical disease) or non-pigmented; micronodular adrenocortical hyperplasias… CONTINUE READING
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