How does ascorbic acid prevent endothelial dysfunction?

@article{May2000HowDA,
  title={How does ascorbic acid prevent endothelial dysfunction?},
  author={J. M. May},
  journal={Free radical biology \& medicine},
  year={2000},
  volume={28 9},
  pages={
          1421-9
        }
}
  • J. M. May
  • Published 2000
  • Chemistry, Medicine
  • Free radical biology & medicine
Human coronary and peripheral arteries show endothelial dysfunction in a variety of conditions, including atherosclerosis, hypercholesterolemia, smoking, and hypertension. This dysfunction manifests as a loss of endothelium-dependent vasodilation to acetylcholine infusion or sheer stress, and is typically associated with decreased generation of nitric oxide (NO) by the endothelium. Vitamin C, or ascorbic acid, when acutely infused or chronically ingested, improves the defective endothelium… Expand
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