How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?

@article{Telmer2011HowDA,
  title={How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?},
  author={Patrick G. Telmer and Cornelia Tolg and James B. McCarthy and Eva Ann Turley},
  journal={Communicative & integrative biology},
  year={2011},
  volume={4 2},
  pages={182-5}
}
The mechanisms responsible for the oncogenic effects of the hyaluronan (HA) receptor and mitotic spindle binding protein, RHAMM, are poorly understood. On one hand, extracellular RHAMM interacts with HA and cellsurface receptors such as CD44 to coordinately activate the MAPK/ERK1,2 pathway, thus contributing to the spread and proliferation of tumor cells. On the other hand, intracellular RHAMM decorates mitotic spindles and is necessary for spindle formation and progression through G2/M and… CONTINUE READING
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