How does a CC double bond cleave in the gas phase? Fragmentation of protonated ketotifen in mass spectrometry.

In the literature, it is reported that the protonated ketotifen mainly undergoes CC double bond cleavage in electrospray ionization tandem mass spectrometry (ESI-MS/MS); however, there is no explanation on the mechanism of this fragmentation reaction. Therefore, we carried out a combined experimental and theoretical study on this interesting fragmentation… CONTINUE READING