How does Parkinson's disease begin? The role of compensatory mechanisms

  title={How does Parkinson's disease begin? The role of compensatory mechanisms},
  author={Jose A. Obeso and Maria C. Rodriguez-Oroz and Jos{\'e} L Lanciego and Manuel Rodr{\'i}guez D{\'i}az},
  journal={Trends in Neurosciences},
Bezard and colleagues [1] have to be congratulated on their studies and discussions of the mechanisms involved in compensation of striatal dopamine loss in Parkinson’s disease (PD). To understand how PD begins and progresses is a major requirement in developing more definitive therapies for PD (A.E. Lang and J.A. Obeso, unpublished). Bezard et al. have conclusively shown that classically accepted dopamine-mediated mechanisms are not primarily involved in the initial compensation of striatal… CONTINUE READING


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