How does ECT work? A new explanatory model and suggestions for non-convulsive applications.

  title={How does ECT work? A new explanatory model and suggestions for non-convulsive applications.},
  author={Ioannis Tsoukalas},
  journal={Medical hypotheses},
  • I. Tsoukalas
  • Published 7 October 2020
  • Psychology
  • Medical hypotheses
2 Citations
Investigating the Role of Leukocyte Telomere Length in Treatment-Resistant Depression and in Response to Electroconvulsive Therapy
The results support previous findings suggesting premature cell senescence in patients with severe psychiatric disorders and suggest that LTL could not be a predictive biomarker of response to ECT.


How Electroconvulsive Therapy Works?: Understanding the Neurobiological Mechanisms
  • Amit Singh, Sujita Kumar Kar
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2017
Different neurobiological mechanisms responsible for the therapeutic efficacy of ECT are reviewed, which brings about various neuro-physiological as well as neuro-chemical changes in the macro- and micro-environment of the brain.
Serendipity Strikes Again: Scopolamine as an Antidepressant Agent in Bipolar Depressed Patients
It is reported that this antidepressant effect occurs in bipolar, as well as unipolar depressed patients, and the clinical and theoretical implications of this findng for difficult to treat bipolar depressed patients is considerable.
A Meta-Analysis of Electroconvulsive Therapy Efficacy in Depression
Some evidence was found that psychosis predicted better response to ECT, and ECT was shown to be superior to medication and simulated ECT.
Sleep deprivation in depression
An overview of clinical and neurobiological responses related to SD in depression is provided and different strategies to stabilize the antidepressant effect of SD have been applied.
The cholinergic system and depression
Current electroconvulsive therapy practice and research in the geriatric population.
During the next decade, research studies should focus on the use of ECT as a synergistic therapy, to enhance other biological and psychological treatments, and prevent symptom relapse and recurrence.
The Emperor's New Drugs: Exploding the Antidepressant Myth
The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus and offers a path society can follow so that the authors stop popping pills and start proper treatment for depression.
The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential
Preclinical data suggest a high potential of such compounds to control seizures, with a strong predictive validity toward human patients, and the discovery of DOPr-agonists without proconvulsant potential stimulates the research on the therapeutic use of neuroprotective potential of the enkephalin/DOPr system.