How does DNA methyltransferase cause oncogenic transformation?

  title={How does DNA methyltransferase cause oncogenic transformation?},
  author={Moshe Szyf and Dr Richard J. Knox and Snezana Milutinovic and Andrew D Slack and Felipe Rocha Rego Caldeira de Ara{\'u}jo},
  journal={Annals of the New York Academy of Sciences},
  pages={156-74; discussion 175-7}
Global hypomethylation of genes and repetitive sequences, as well as hypermethylation of certain genes known to be involved in tumor suppression, are observed concurrently in cancer cells. Aberrant expression of DNA methyltransferase 1 (dnmt1) is a downstream effector of multiple tumorigenic pathways, and several data suggest that dnmt1 plays a causal role in these pathways. These data raise two critical questions: Why does ectopic expression of dnmt1 transform cells? and How can global… CONTINUE READING
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