How do you distinguish benign from malignant extranodal small B-cell proliferations?

@article{Kurtin1999HowDY,
  title={How do you distinguish benign from malignant extranodal small B-cell proliferations?},
  author={Paul James Kurtin},
  journal={American journal of clinical pathology},
  year={1999},
  volume={111 1 Suppl 1},
  pages={
          S119-25
        }
}
The diagnostic criteria for malignancy for small B-cell lymphoproliferative disorders in extranodal sites are controversial. However, a multiparameter approach that integrates clinical features, morphologic features, phenotype, and genetics techniques allows for a confident separation of lymphomas from lymphoid hyperplasia in most cases. By morphologic features, formation of a mass, tissue architectural effacement, cellular monomorphism, cytologic atypia, presence of proliferation centers, and… CONTINUE READING