How do you design randomised trials for smaller populations? A framework

  title={How do you design randomised trials for smaller populations? A framework},
  author={Mahesh K B Parmar and Matthew R. Sydes and Tim P Morris},
  booktitle={BMC medicine},
How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?We present an ordered framework for designing randomised trials to address the problem when the ideal sample size is considered larger than the number of participants that can be recruited in a reasonable time frame. Staying with the frequentist approach that is well accepted and understood in large trials, we propose a framework that includes small… CONTINUE READING
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