How do side chains orient globally in protein structures?

  title={How do side chains orient globally in protein structures?},
  author={Aimin Yan and Robert L. Jernigan},
  volume={61 3},
An angle Omega is defined to serve as a metric for global side-chain orientations, which reflects the orientation of the side chain relative to the radial vector from the center of the protein to an amino acid. The side-chain orientations of buried residues exhibit characteristically different orientations than do exposed residues, in both monomeric and dimeric structures. Overall, buried side chains point mostly inward, whereas surface side chains tend to point outward from the surface. This… CONTINUE READING