How do normal and leukemic white blood cells egress from the bone marrow?

@article{Petrides1990HowDN,
  title={How do normal and leukemic white blood cells egress from the bone marrow?},
  author={Petro E. Petrides and Klaus H. Dittmann},
  journal={Blut},
  year={1990},
  volume={61},
  pages={3-13}
}
Under normal circumstances only mature granulocytes and monocytes cross the bone marrow sinus wall, a trilaminar structure consisting of endothelial cells, a discontinuous basal membrane and an adventitial cell layer in order to get access to the blood circulation. In leukemia, however, immature white blood cells are able to traverse the barrier and to appear in the blood stream. Very little is known about the regulatory processes which govern the egress of white blood cells in healthy… CONTINUE READING
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