How do normal and leukemic white blood cells egress from the bone marrow?

  title={How do normal and leukemic white blood cells egress from the bone marrow?},
  author={Petro E. Petrides and Klaus H. Dittmann},
Under normal circumstances only mature granulocytes and monocytes cross the bone marrow sinus wall, a trilaminar structure consisting of endothelial cells, a discontinuous basal membrane and an adventitial cell layer in order to get access to the blood circulation. In leukemia, however, immature white blood cells are able to traverse the barrier and to appear in the blood stream. Very little is known about the regulatory processes which govern the egress of white blood cells in healthy… CONTINUE READING
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Drug-induced agranulocytosis: haematological remission upon treatment with recombinant GM-CSF (submitted for publication

  • PE Petrides, HH Gerhartz
  • 1990
2 Excerpts

Leukemic cells (HL-60) constitutively release a protease (apolysin) which may facilitate their egress from bone marrow (submitted for publication

  • KH Di t tmann, PE Petrides
  • 1990
1 Excerpt

Attachment of hemopoietic progenitor cells to stromal cells is mediated by membrane - associated proteoglycans and fibronectin binding sites in the progenitor cells

  • L Zamboni, DC Pease
  • Exp Hematol
  • 1989