How do SAP family deficiencies compromise immunity?

  title={How do SAP family deficiencies compromise immunity?},
  author={Zhongjun Dong and Andr{\'e} Veillette},
  journal={Trends in immunology},
  volume={31 8},
The signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) family of adaptors couples SLAM family receptors to activating intracellular signaling pathways that drive immune cell activation or differentiation. In the absence of SAP family adaptors, SLAM family receptors become inhibitory, possibly through coupling to the Src-homology-2-containing phosphatases. This "switch-of-function" of SLAM family receptors provides an explanation for the severe immune dysfunctions observed… CONTINUE READING


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