How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

@article{Labib2010HowDC,
  title={How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?},
  author={Karim Labib},
  journal={Genes & development},
  year={2010},
  volume={24 12},
  pages={1208-19}
}
Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during the initiation of chromosome replication, and a key feature of this process is the activation of the replicative DNA helicase in situ at each origin of DNA replication. A series of… CONTINUE READING
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