How different is oxycodone from morphine?

  title={How different is oxycodone from morphine?},
  author={E. Kalso},
  • E. Kalso
  • Published 2007
  • Medicine
  • PAIN
  • This issue of Pain includes another paper [15] by the Australian group that has published a series of studies on rodents, arguing that oxycodone is a j-opioid receptor agonist. They propose that this property can explain the discrepancy between the relatively weak l-opioid receptor affinity of oxycodone compared with morphine and its better clinical efficacy compared with morphine. Even though the evidence for this is circumstantial and no other group has replicated the results, the clinicians… CONTINUE READING
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