How curved membranes recruit amphipathic helices and protein anchoring motifs.

Abstract

Lipids and several specialized proteins are thought to be able to sense the curvature of membranes (MC). Here we used quantitative fluorescence microscopy to measure curvature-selective binding of amphipathic motifs on single liposomes 50-700 nm in diameter. Our results revealed that sensing is predominantly mediated by a higher density of binding sites on… (More)
DOI: 10.1038/nchembio.213

Topics

Cite this paper

@article{Hatzakis2009HowCM, title={How curved membranes recruit amphipathic helices and protein anchoring motifs.}, author={Nikos S Hatzakis and V. Bhatia and Jannik Bruun Larsen and Kenneth L Madsen and Pierre-Yves Bolinger and Andreas H Kunding and John J. Castillo and Ulrik Gether and Per Hedeg̊ard and Dimitrios G. Stamou}, journal={Nature chemical biology}, year={2009}, volume={5 11}, pages={835-41} }