How contexts promote and prevent relapse to drug seeking.

@article{Khoo2017HowCP,
  title={How contexts promote and prevent relapse to drug seeking.},
  author={Shaun Y-S Khoo and Gabrielle D Gibson and Asheeta A Prasad and Gavan P McNally},
  journal={Genes, brain, and behavior},
  year={2017},
  volume={16 1},
  pages={
          185-204
        }
}
The contexts where drugs are self-administered play an important role in regulating persistent drug taking and in relapse to such taking after periods of abstinence. Here, we review the behavioral and brain mechanisms enabling contexts to promote and prevent relapse to drug seeking. We review the key brain structures, their neuropharmacology and their connectivity. We discuss the similarities and differences between the mechanisms for context-induced reinstatement of drug seeking vs. other… CONTINUE READING

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