How conditioned stimuli acquire the ability to activate VTA dopamine cells: A proposed neurobiological component of reward-related learning
@article{Zellner2010HowCS, title={How conditioned stimuli acquire the ability to activate VTA dopamine cells: A proposed neurobiological component of reward-related learning}, author={M. Zellner and R. Ranaldi}, journal={Neuroscience & Biobehavioral Reviews}, year={2010}, volume={34}, pages={769-780} }
The ability to learn about conditioned stimuli (CS) associated with rewards is a crucial adaptive mechanism. Activity in the mesocorticolimbic dopamine (DA) system, as well as in the ventral tegmental area (VTA), is correlated with responding to and learning about CSs. The mechanism by which VTA neurons become activated by signals associated with conditioned stimuli is not fully understood. Our model suggests that NMDA receptor stimulation in the VTA allows originally weak glutamate signals… CONTINUE READING
Topics from this paper
62 Citations
Dopamine and reward seeking: the role of ventral tegmental area
- Psychology, Medicine
- Reviews in the neurosciences
- 2014
- 48
The effects of VTA NMDA receptor antagonism on reward-related learning and associated c-fos expression in forebrain
- Psychology, Medicine
- Behavioural Brain Research
- 2011
- 30
- PDF
The strength of reward-related learning depends on the degree of activation of ventral tegmental area dopamine neurons
- Chemistry, Medicine
- Behavioural Brain Research
- 2018
- 2
Concurrent antagonism of NMDA and AMPA receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats
- Psychology, Medicine
- Behavioural Brain Research
- 2016
- 4
A food-associated CS activates c-Fos in VTA DA neurons and elicits conditioned approach
- Psychology, Medicine
- Behavioural Brain Research
- 2012
- 16
A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions
- Psychology, Medicine
- Neuroscience
- 2011
- 119
- PDF
Motor skill learning and reward consumption differentially affect VTA activation
- Biology, Medicine
- Scientific Reports
- 2017
- 15
- PDF
The Functions of Dopamine in Operant Conditioned Reflexes
- Psychology
- Neuroscience and Behavioral Physiology
- 2019
Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning.
- Biology, Medicine
- Cell reports
- 2016
- 19
Extinction reveals that primary sensory cortex predicts reinforcement outcome
- Psychology, Medicine
- The European journal of neuroscience
- 2012
- 38
- PDF
References
SHOWING 1-10 OF 235 REFERENCES
NMDA receptor antagonism in the ventral tegmental area impairs acquisition of reward-related learning
- Psychology, Medicine
- Behavioural Brain Research
- 2009
- 38
- PDF
Cue-evoked firing of nucleus accumbens neurons encodes motivational significance during a discriminative stimulus task.
- Psychology, Medicine
- Journal of neurophysiology
- 2004
- 169
- PDF
Contrasting effects of dopamine and glutamate receptor antagonist injection in the nucleus accumbens suggest a neural mechanism underlying cue‐evoked goal‐directed behavior
- Psychology, Medicine
- The European journal of neuroscience
- 2004
- 91
The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues
- Biology, Medicine
- The Journal of Neuroscience
- 2004
- 220
- PDF
Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement.
- Biology, Medicine
- Annual review of neuroscience
- 2007
- 535
- PDF
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
- Psychology, Medicine
- The Journal of Neuroscience
- 2002
- 189
- PDF
The role of dopamine in locomotor activity and learning
- Psychology, Medicine
- Brain Research Reviews
- 1983
- 809
- PDF
Behavioral associations of neuronal activity in the ventral tegmental area of the rat
- Psychology, Medicine
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 1994
- 97
- PDF
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
- Psychology, Medicine
- Neuroscience
- 2000
- 876
- PDF
Dopamine Cells Respond to Predicted Events during Classical Conditioning: Evidence for Eligibility Traces in the Reward-Learning Network
- Psychology, Medicine
- The Journal of Neuroscience
- 2005
- 387
- Highly Influential
- PDF