How clonal are human mitochondria?

@article{EyreWalker1999HowCA,
  title={How clonal are human mitochondria?},
  author={A. Eyre-Walker and N. Smith and John Maynard Smith},
  journal={Proceedings of the Royal Society of London. Series B: Biological Sciences},
  year={1999},
  volume={266},
  pages={477 - 483}
}
Phylogenetic trees constructed using human mitochondrial sequences contain a large number of homoplasies. These are due either to repeated mutation or to recombination between mitochondrial lineages. We show that a tree constructed using synonymous variation in the protein coding sequences of 29 largely complete human mitochondrial molecules contains 22 homoplasies at 32 phylogenetically informative sites. This level of homoplasy is very unlikely if inheritance is clonal, even if we take into… Expand

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