How cells handle cholesterol.

  title={How cells handle cholesterol.},
  author={Keila Simons and Elina Ikonen},
  volume={290 5497},
Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Recent advances suggest that cholesterol exerts many of its actions mainly by maintaining sphingolipid rafts in a functional state. How rafts contribute to cholesterol metabolism and transport in the cell is still an open issue. It has long been known that cellular cholesterol levels are precisely controlled by biosynthesis, efflux from cells, and influx of lipoprotein cholesterol into… CONTINUE READING
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Meer for helpful discussions and for critical reading of the manuscript. Supported by the Deutsche Forschungsgemeinschaft and the Academy of Finland

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