How cells flow in the spreading of cellular aggregates.

@article{Beaune2014HowCF,
  title={How cells flow in the spreading of cellular aggregates.},
  author={Gr{\'e}gory Beaune and Tomita Vasilica Stirbat and Nada Khalifat and Olivier Cochet-Escartin and Simon U Garcia and Vasily Gurchenkov and Michael P. Murrell and Sylvie Dufour and Damien Cuvelier and Françoise Brochard-Wyart},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 22},
  pages={
          8055-60
        }
}
Like liquid droplets, cellular aggregates, also called "living droplets," spread onto adhesive surfaces. When deposited onto fibronectin-coated glass or polyacrylamide gels, they adhere and spread by protruding a cellular monolayer (precursor film) that expands around the droplet. The dynamics of spreading results from a balance between the pulling forces exerted by the highly motile cells at the periphery of the film, and friction forces associated with two types of cellular flows: (i… CONTINUE READING
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