How can antipsychotics cause Diabetes Mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins.

@article{Starrenburg2009HowCA,
  title={How can antipsychotics cause Diabetes Mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins.},
  author={F C J Starrenburg and Jan P.A.M. Bogers},
  journal={European psychiatry : the journal of the Association of European Psychiatrists},
  year={2009},
  volume={24 3},
  pages={164-70}
}
The prevalence of Diabetes Mellitus (DM) is becoming a serious public health problem. The use of atypical antipsychotics has been associated with disruption of the glucose metabolism and therefore with causing DM. The underlying mechanisms are unknown, but knowledge of the differences between the pharmacological features of various antipsychotics combined with their diabetogenic profile might help us to understand those mechanisms. This article describes how the binding of various essential… CONTINUE READING
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